The drug concentrations of two drugs on the coordinates of the isobol are normalized by the corresponding EDx doses or concentrations. Several relevant points need to be considered: However, the study of patterns of possible metabolic and biological interactions in preclinical models, as well as scheduling, should improve the development of most drug combinations. Synergism at what dose level? Whereas the iso-effective graph in the classic isobol is represented by a straight diagonal line, the iso-effective graph in the conservative isobol is represented by a convex upward curve.Įach subsequent set should also start on a new line. CalcuSyn for Windows, Multiple-drug dose-effect analyzer and manual. Manual and Software, Biosoft, Cambridge, U.K., Chou, T.-C. and antagonism, respectively (Source: CalcuSyn manual, Biosoft, ). combination-index data generated by CalcuSyn software analyses. 年1月23日 CalcuSyn is a software tool whose main purpose is to aid individuals in analyzing mixed drug treatments, a more and more used practice in.
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